[Eeglablist] How to Use EEGLab in Clinical Psychopharmacology Research?

[fearfree]

I am trying to use EEGLab to make inferences about neurotransmitter
abnormalities in neuropsychiatry patients.
 
Using Z-normalized spectral topographic maps, it is possible to define
abnormal frequency bands in particular electrode locations (ie. An OCD
patient with left dysdiadochokinesis and MRI evidence of right frontal
gliosis had abnormally high right frontal Delta power).
 
Having computed CSD localizations of ICA Maps, there appears to be good
correspondence between dipole locations and directions and known
projections to cortex (ie. There was a medially directed dipole in this
patient's right lenticular nucleus associated with an ICA Map showing
right frontal deficit and left central activation. Perhaps this
corresponds to striatal disinhibition and activation of contral lateral
ventral-lateral thalamic efferents to Brodman 4 cortex?).  Further, FFT
on component activity during that epoch in this patient showed a
predominance of 3 Hz rhythm.  Changes in dipoles as a function of
neuropharmacologic intervention in known transmitter specific parts of
this circuit might be used to define neurotransmitter abnormalities.
 
Do EEG list members think these are valid inferences to make about
CSD/Component Properties in pharmacoEEG studies, or no, and why so?
 
Thanks,
 
Cary Hamlin
 
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