[Eeglablist] How to Use EEGLab in Clinical Psychopharmacology Research?

[Arnaud Delorme]

> it is possible to define abnormal frequency bands in particular 
> electrode locations (ie. An OCD patient with left dysdiadochokinesis 
> and MRI evidence of right frontal gliosis had abnormally high right 
> frontal Delta power).
>
> Having computed CSD localizations of ICA Maps,
>
You mean you took the laplacian of the ICA scalp maps to compute ICA map 
current source density? Why?

> there appears to be good correspondence between dipole locations and 
> directions and known projections to cortex (ie. There was a medially 
> directed dipole in this patient's right lenticular nucleus associated 
> with an ICA Map showing right frontal deficit and left central 
> activation. Perhaps this corresponds to striatal disinhibition and 
> activation of contral lateral ventral-lateral thalamic efferents to 
> Brodman 4 cortex?).
>
I would not venture to such conclusions based on a single subject. On 
what do you base your reasoning?

> Further, FFT on component activity during that epoch in this patient 
> showed a predominance of 3 Hz rhythm.  Changes in dipoles as a 
> function of neuropharmacologic intervention in known transmitter 
> specific parts of this circuit might be used to define 
> neurotransmitter abnormalities.
>
Do you intend to study how ICA equivalent dipole locations and 
orientations evolve as a function of the neuropharmacologic 
intervention? I would personally rather regroup the two conditions 
(control and treated), apply ICA, then study how your central medial 
component behaves. Its temporal/spectral activity probably differs 
between the two conditions.

Hope this help

Best

Arno
-- 

* Arnaud Delorme <http://www.sccn.ucsd.edu/%7Earno>, Ph.D.* , SCCN, 
UCSD, San Diego, USA

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