<div dir="ltr"><div><div><div><div><div><div>Dear EEGLAB users,<br><br></div>I'm happy to announce that our recent paper on skull conductivity estimation is now accepted for publication in Neuroimage.<br><br></div><div>You can find the accepted version at:
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<div><a href="http://sccn.ucsd.edu/%7Escott/pdf/AkalinAcar_SCALE_NeuroImage_in_press_0815.pdf" target="_blank">Preprint of the accepted version</a><br></div></div><div><br></div><b>Title</b>: Simultaneous head tissue conductivity and EEG source location estimation<br><br></div><b>Authors</b>: Z. Akalin Acar, C. Acar, S. Makeig<br><br></div><b>Abstract</b>: <br>Accurate
electroencephalographic (EEG) source localization requires an
electrical head model incorporating accurate geometries and conductivity
values for the major head tissues. While consistent conductivity values
have been reported for scalp, brain, and cerebrospinal fluid, measured
brain-to- skull conductivity ratio (BSCR) estimates have varied between 8
and 80, likely reflecting both inter-subject and measurement method
differences. In simulations, mis-estimation of skull conductivity can
produce source local- ization errors as large as 3 cm. Here, we describe
an iterative gradient-based approach to Simultaneous tissue
Conductivity And source Location Estima- tion (SCALE). The scalp
projection maps used by SCALE are obtained from near-dipolar effective
EEG sources found by adequate independent compo- nent analysis (ICA)
decomposition of sufficient high-density EEG data. We applied SCALE to
simulated scalp projections of 15 cm2-scale cortical patch sources in an
MR image-based electrical head model with simulated BSCR of 30.
Initialized either with a BSCR of 80 or 20, SCALE estimated BSCR as
32.6. In Adaptive Mixture ICA (AMICA) decompositions of (45-min,
128-channel) EEG data from two young adults we identified sets of 13 in-
dependent components having near-dipolar scalp maps compatible with a
single cortical source patch. Again initialized with either BSCR 80 or
25, SCALE gave BSCR estimates of 34 and 54 for the two subjects
respectively. The ability to accurately estimate skull conductivity
non-invasively from any well-recorded EEG data in combination with a
stable and non-invasively ac- quired MR imaging-derived electrical head
model could remove a critical barrier to using EEG as a sub-cm2-scale
accurate 3-D functional cortical imaging modality.<br><br></div>Thank you,<br></div>Zeynep Akalin Acar</div>