[Eeglablist] Can amygdala activity be detected on the scalp?

[Alexander J. Shackman]

It's been done with epileptic spikes, so I see no reason it couldn't
be done with sufficient averaging of ERPs in order to get adequate SNR
(per Pal's comment).

Alex Shackman



On 12/31/05, "Pål G. Larsson" <pal.g.larsson at epilepsy.no> wrote:
> Teresa Wong wrote:
>
> > Dear colleagues,
> >
> > I would like to hear your views on whether scalp ERPs can reflect
> > activity of the amygdala.
> > Is it possible/valid to localize dipole sources (using 128-channel
> > recordings, emotional faces as stimuli) in subcortical brain regions,
> > limbic areas, amygdala, etc?
>
>
> One of Paul Nunez works look into the possibilty of recording small
> foci. I guess to make it simple, it all cooks down to the degree of
> syncrony and the signal/noise ratio. E.g. you can record brainstem
> potentials, but you have to "cheat" by doing averanging (thousand of
> samples).
>
> To record spontanious amygdala activity, you have a signal that is low
> due to distance. On the other side you have cortical activity from large
> cortex-areas that are near the recording givening lots of "noise". You
> need to get rid of the noise -> averaging. So, in ERP-studies you must
> average. Then you get the next problem: Can you have a paradigm that
> gives stable response for hundreds or probably thousands of avergares?
>
> Regards
>
> Pål G. Larrson
>
> Head of. dept
> Dept. of neurodiagnostics
> National Centre for Epilepsy, Norway
>
> >
> > Wishing you all a very happy and healthy 2006 with much success in
> > research!
> >
> > Teresa
> > --
> > Teresa Ka Wai Wong
> > PhD Student
> > Department of Psychiatry
> > The University of Hong Kong
> >
> >
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> >
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--
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Alexander J. Shackman
Laboratory for Affective Neuroscience | Waisman Laboratory for Brain
Imaging & Behavior
University of Wisconsin-Madison
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