[Eeglablist] EEGLAB advice inquiry

[Makoto Miyakoshi]

Hi Sarah,

   1. Human or animal?
   2. Type of the electrode?
   3. Where to record?
   4. Reference electrode?
   5. How many datasets?
   6. Type and modality of the stimulus?
   7. What is your definition of 'cortical excitability'?

0.18 s time window sounds like you target either an auditory or an sensory
response at their primary cortex?

Any discrete and independent stimulus evokes supramodal extralemniscal
thalamo-cortical response, so you need to be careful not to mix it up with
modality-specific lemniscal responses. See my recent paper summarizing this
point. https://urldefense.com/v3/__https://academic.oup.com/cercor/article-abstract/35/6/bhaf141/8163460__;!!Mih3wA!GL6DQOmnPJZaZnF8Jh444yaC7fc9ztV3F_CCyybkwc2wxv6HYuQIOtN-hEhV2K08hymwRNKnafV1Ecm1ZA5Kh_oBp9M$ 

Technically, time-frequency or freq-freq analysis you listed is a way to
go. However, you also want to include a simple ERP waveform analysis as
well for validation.

If you are recording either from the primary auditory cortex, for example,
you should be able to observe a very early potential. The first peak at
around 10 ms is a pure lemniscal response. Anything after 20-30 ms is more
or less a mixture of EXLEM (Galambos et al., 1981), and the one at around
100 ms, a typical 'AEP', is mostly EXLEM-contributed and not from the
auditory cortex any more. However, you need to cover broader areas of the
cortex to confirm this, which you cannot!

If it is an auditory project, let me know. I'm curious.

Makoto

On Wed, Aug 27, 2025 at 3:04 PM Sarah Rehmani via eeglablist <
eeglablist at sccn.ucsd.edu> wrote:

> Good afternoon,
>
> I hope this email finds you well.
>
> I was hoping to reach out regarding any insights someone may have about
> the use of EEGLAB to analyze single-channel cortical electrode EEG
> recordings. I'm currently looking to analyze 0.18-second recordings taken
> before and immediately after a short stimulation pulse. My goal is to
> compare cortical excitability across multiple of these recordings. I'm
> looking into approaches such as comparing the power spectra in the alpha
> band, as well as comparing comodulograms for theta-gamma coupling. However,
> I was hoping to reach out to the EEGLAB mailing list and see if anyone has
> any guidance on how to approach this type of single channel data, as well
> as how to assess excitability from these EEG recordings. Any suggestions
> you may have would be incredibly useful to me. I'm happy to discuss this in
> further detail over email as well. Thank you!
>
> Best,
> Sarah Rehmani
> srehm041 at uottawa.ca
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