[Eeglablist] Source localization and hippocanpus

[Richards, John]

The hippocampus, caudate, putamen, amygdala, sometimes are classified with "cortex" as gray matter and people might try to do source analysis.  However, only the cortex has the perpendicular pyramidal structure that conducts current to the scalp, and the "subcortical" brain areas do not have the correct structure to generate current on the scalp.  If you put source locations in these areas and do source analysis you will get "something", likely due to activity in other brain areas, noise, or other non-neuron activity.

I think that a couple of the "internal" cortex ROIs, like the insula, have the cortex structure to generate current.  But its possible that it cannot be measured because the area is relatively far from the scalp and any current would be small.

John

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John E. Richards
Carolina Distinguished Professor
Department of Psychology
University of South Carolina
Columbia, SC  29208
Dept Phone: 803 777 2079
Fax: 803 777 9558
Email: richards-john at sc.edu
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-----Original Message-----
From: eeglablist <eeglablist-bounces at sccn.ucsd.edu> On Behalf Of Cedric Cannard via eeglablist
Sent: Wednesday, January 14, 2026 3:43 PM
To: EEGLAB List <eeglablist at sccn.ucsd.edu>
Subject: [Eeglablist] Source localization and hippocanpus

Hi everyone,

My understanding is that it is impossible to reliably pick up activity from the hippocampus when doing any form of source localization/reconstruction from 64 channels EEG data (or more?). Is that still correct or are there solutions I am not aware of?

Thanks,

Cedric

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