[Eeglablist] Open collaboration project: Multi-model Anatomical Grouping of Independent Components (MMAGIC)

[Makoto Miyakoshi]

Hi Marjan and list,

I'd like to propose a small open collaboration project.

The idea is that we want to use anatomical ROI membership as a common
coordinate across subjects, instead of relying on conventional IC
clustering approach in EEGLAB STUDY. In the proposed approach, users
specify an anatomical ROI, optionally with a distance tolerance, and ICs
whose source models fall within that region are collected across subjects.
In this implementation, anatomical ROI membership replaces IC clustering as
the cross-subject correspondence rule.

Here is a prototype I originally developed for a project with Ilaria
Berteletti, which uses standard current dipole models. Although we
ultimately did not use it in that study, I can tell you it worked better
than I thought.

https://urldefense.com/v3/__https://github.com/MakotoMiyakoshi/MMAGIC__;!!Mih3wA!AoKTTZuSu2CVqhzgmxuMpdjqVNFyIVR-LQZYBeLZwVRfqta0reT9bYiTM3uHevgACv2_Bf8HE91bDX8kg7QX9GoBaAI$ 
<https://urldefense.com/v3/__https://github.com/MakotoMiyakoshi/AnatomicalROIGroupICA__;!!Mih3wA!AoKTTZuSu2CVqhzgmxuMpdjqVNFyIVR-LQZYBeLZwVRfqta0reT9bYiTM3uHevgACv2_Bf8HE91bDX8kg7QXcKIZKQg$ >

I cleaned the implementation to publish here and tested it on real
ICA/DIPFIT datasets; details are available in the repository.

However, my recent work (under review) showed that more than 80% of the
pre-qualified brain ICs by IC Label were localized deeper than
physiologically plausible cortical source depths:

https://urldefense.com/v3/__https://www.medrxiv.org/content/10.64898/2026.01.23.26344529v2__;!!Mih3wA!AoKTTZuSu2CVqhzgmxuMpdjqVNFyIVR-LQZYBeLZwVRfqta0reT9bYiTM3uHevgACv2_Bf8HE91bDX8kg7QXDaIe1jw$ 

So it's time to try different cortex-constrained source estimates such as
MNE, the LORETA family, LCMV, or other methods. The results can then be
compared within a common anatomical ROI space. Hence MMAGIC: Multi-model
Anatomical Grouping of Independent Components.

Marjan and I would like to develop this into a methodological/software
project. If anyone is interested in contributing a source-localization
method, atlas-mapping approach, validation with empirical data, or
methodological idea, you are welcome to join us. Please let us know.

Makoto