Arnaud DELORME, Ph.D.
Work: +1-858-458-1927 x 15
Swartz Center for Computational Neuroscience
Institute for Neural Computation, 0961, UCSD
La Jolla, CA 92093-0961
Current Position and interestsI am a principal investigator at the CNRS CERCO laboratory in Toulouse, France since 2005. I am presently interested in studying neural correlates of neurofeedback learning as well as meditation experience using spectral analysis and indepedent component analysis of the electro-encephalography (EEG) signal. I also spend half of the year in San Diego California collaborating with Scott Makeig at the institute of Neural Computation at UCSD for the continued developpement of the EEGLAB software for EEG analysis.
Ongoing research projects and fundingA human electrophysiology, associated anatomic data and integrated tool resource (HeadIT) (co-investigator with Scott Makeig on NIH R01 grant 2009-2011). This project aims at providing a customizable data pre-processing facility for EEG data using existing BIRN database nodes and available high-performance computing facilities. An international database for EEG data will be created and tools to preprocess the data automatically using EEGLAB tools will be developped.
New Analysis Methods for Human Electro-Encephalography Data (co-investigator with Scott Makeig on NIH R01 grant 2008-2012). The EEGLAB software environment (http://sccn.ucsd.edu/eeglab), a now widely used open source software resource for analysis and visualization of brain dynamics from electrophysiological data. EEGLAB is designed to facilitate a major evolutionary step now taking place in the field of human electrophysiology. Using EEGLAB, human electroencephalographic (EEG), magnetoencephalographic (MEG), and invasive electrophysiological studies are increasingly making use of modern signal processing advances including time/frequency analysis, source localization onto magnetic resonance images of the head, three-dimensional and animated visualization methods, and spatial filtering including independent component analysis (ICA), applied not only to trial averages but directly to the high-dimensional single-trial data.
Neural correlates of meditation practice (PI of a grant from the BIAL fundation; collaboration with Rael Cahn, MD, PhD). One of the exciting developments in the cross-cultural study of human consciousness consists of studying non-classical conscious states such as self-induced states and traits due to intensive meditation practice. However, despite decades of interest in this field and renewed interest over the past 10 years, a major current challenge in meditation research continues to be the delineation of the distinct neural correlates to meditative experience across the varied meditative practice types, as well as the correlation between brain activity changes and physiologic parameters such as autonomic tone, breathing, and heart rate activity. A prime goal of the current research proposal is to use the same equipment to assess high-density EEG with concurrent galvanic skin response, breath rate, and heart rate variability measures due to meditation as well as to assess how attentionally-demanding and emotional stimuli are processed in a range of practices spanning the continuum between two of the major poles of meditative engagement of attention - open monitoring vs. attentional focusing. This project is conducted at the Meditation Research Institute in Rishikesh, India.
Neural correlates of meta-consciousness events during mind-wandering (PI of a small grant from the Mind and Life fundation 2005-; a PhD fellowship was awarded by the CNRS to pursue this project in 2008). Reading a book, most people have had experience of finding that their attention has been drifting towards self-centered matters. After some time (seconds to minutes), the reader realizes he is mind wandering, and brings back his attention to the reading matter. These self-aware realization events are usually termed meta-consciousness events (Schooler, 2002). One may think that avoiding these attention shifts is only a matter of concentration and willingness to carry out a mental task. Yet, after weeks, months, or years of any meditation practice, meditators learn that these events seem to just happen, however hard they may try to avoid them. This project aim at studying these events.
Neural correlates of neurofeedback learning (FRM fundation grant; a PhD fellowship was awarded by the French Ministry of Research to pursue this project in 2008). Neurofeedback may provide a promising alternative procedure to drug treatment in a variety of mental disorders. Neurofeedback involves training patients to direct their brain rhythms away from their pathological EEG signature by decreasing power at specific frequencies and scalp electrodes. I will use advanced analysis to identify brain sources modulated in neurofeedback training using independent component analysis. I anticipate that this research will open new perspectives in neuron-imaging by allowing us to show that controlling activity of specific brain areas can specifically alter the behavior of subjects.
ICA decomposition and source localisation (co-PI with Sylvain Baillet on NeuroInformatics CNRS grant). Electroencephalography (EEG) and magnetoencephalography (MEG) signals have fine temporal resolution but suffer from poor spatial resolution. Although distributed MEG/EEG source imaging now provides an instantaneous model of neural currents at each brain voxel from surface recordings, data exploration still remains essentially qualitative as activation patterns are smeared onto the cortical surface. Our primarily methodological aim consists in unraveling possibly overlapping activation maps of MEG/EEG generators by combining distributed EEG/MEG source models with a data separation approach based on Independent Component Analysis (ICA).
2005-present CNRS principal investigator at the CERCO laboratory in France, and visiting faculty at the university of San Diego California. 2004-2005 Project scientist in Scott Makeig's laboratory at the institute of Neural Computation at UCSD (University of California San Diego). Sept-Nov 2004 Visiting faculty for the Birla Institute of Technology, Bombay, India. Setting up a brain-computer interface laboratory and teaching the neuroscience course for the Master of Consciousness Studies. 2003-2004 Post-doctoral fellow in Scott Makeig's laboratory at the institute of Neural Computation at UCSD (University of California San Diego). 2000-2003 Post-doctoral fellow in Terry Sejnowski's laboratory at the Salk Institute for Biological Studies and visiting scholar at the institute of Neural Computation at UCSD (University of California San Diego).
1997-2000 PhD student (MNERT 3 years fellowship from french government) in CNRS Brain and Cognition Center (CERCO), Toulouse, France.
Winter 2002 FENS winter school on "dynamic aspects of brain functions : methodologies, concepts, models", Kitzbuhel, Austria (35 participants). Winter 2001 Academic Writing Classes (27 hours), University of San Diego California, A+ grade.
August 2001 Workshop for the Analysis of Neural Data, Marine Biology Laboratories, Woods Hole, USA (20 participants).
1997-2000 Research Thesis "Rapid visual processing in monkeys, humans and machines : a forward-looking view". Co-directed by S. Thorpe and M. Fabre-Thorpe, CERCO, Toulouse, France. Download Thesis (PDF format, in french).
Sept. 1999 EU Advanced Course in Computational Neuroscience, ICTP, Trieste, Italy (30 participants).
1996-1997 DEA of Cognitive Sciences (courses associated with PhD), Paris VI University, Paris, France.
1995-1996 Maîtrise d'Informatique (Programming level 2), Paris XII University - Rank 'Major' (1st) with jury's felicitations.
Maîtrise de Biologie (Cell Biology level 2), Paris XII University - Rank 'Major'.
1994-1995 Licence d'Informatique (Programming level 1), Paris XII University - Rank 'Major'.
Licence de Biologie (Cell Biology level 1), Paris XII University - Rank 'Major'.
1992-1994 'DEUG SSM' (bachelor of mathematics and physics), Paris XII University - Rank 'Major' for two consecutive years among about 1000 students.
Honors and fellowships
2006 ANT company 10-year anniversary young investigator award (reward 3 young scientists for their outstanding contribution to the field of EEG research) 2002 Bretencourt Schueller Foundation young researcher award 2001 Medical Research Foundation fellowship 2000 Computer science organization INRIA fellowship 2000 Naturalia and Biologia fellowship 1997 French government MNERT thesis fellowship 1992-1996 Ranked Major (first) for B. Sc. and both MSEE (passed simultaneously).
- Workshop organization: Main organizer of the 3-day EEGLAB workshop, 2004 in La Jolla (CA USA), 2005 in Porto (Portugal), 2006 in Singapore. Three workshops are organized in 2007 one in France, on the USA after the SFN conference and one in Chile. Organized an "Independent Component Analysis and Imaging Techniques" workshop session at the Computational Neuroscience Meeting 2001 (Pacific Grove, USA). Organized a "Spike-time based plasticity" workshop session at the Computational Neuroscience Meeting 2000 (Bruges, Belgium).
- Gave talks at the 10th conference on "Toward a science of consciousness" (Tucson, AZ, 2004), the 3rd International Conference on ICA and Blind Source Separation (Del Mar, CA, 2001), the monthly Salk Institute research talks (2001, La Jolla, USA), the monthly Sloan Center for Theoretical Biology research talks (2001, La Jolla, USA), the Annual French Neuroscience Meeting 2001 (Toulouse, France), the Annual Symposium on Neural Computation 2001 (La Jolla, USA), the Annual Computational Neuroscience Meeting 2001 (Pacific Grove, USA), the Annual Meeting of the French Society of Psychology 1999 (Toulouse, France), and a variety of small workshops and laboratories (MIT, Neuroscience Institute, LAAS, Laval University, ...).
- Review submitted papers for
Proceedings of the National Academy of Sciences USA PLOS One Cerebral Cortex Neuroimage Journal of Clinical Neurophysiology (JCNP) Clinical Neurophysiology (Elsevier) Journal of Computational neuroscience NIPS Journal of Neuroscience Methods Neuroreport European Journal of Neuroscience Information science EURASIP Journal on Advances in Signal Processing IET Communication IEEE Transactions on Neural Systems & Rehabilitation Engineering Brain Research IEEE Transactions on Neural Networks Neural Computation IEEE Transactions on Circuits and Systems Biological Psychology IEEE Signal Processing Letters Neuroinformatics IEEE Transactions on Biomedical Engineering Signal Processing IEEE Transactions on Systems, Man, and Cybernetics Electronic letters IEE Proceedings - Vision, Image and Signal Processing Neurocomputing Eurasip Journal on Advanced Signal Processing BMC Neuroscience Brains, Minds, and Media Journal of Neurophysiology Brain research bulletin Behavioral Brain Research International Journal of Psychophysiology Physiological measurements Medical & Biological Engineering & Computing Psychophysiology Computer Methods and Programs in Biomedicine
- Reviewer and panel member for the NEST program of the European Commison (FP6) in 2004-2005. Reviewer of 41 applications for the ERC call for young investigator (FP7) in 2007.
- Monthly research talk organizer and webmaster of the Society for Research Fellow at The Salk Institute for Biological Studies from 2001 to 2003 (www.srf.salk.edu).
- Member of the Cognitive Neuroscience Society since 2000, the Society for Neuroscience 2000.
- Chief developer and webmaster for EEGLAB software and administrator of two mailing lists (firstname.lastname@example.org containing 3000 users and email@example.com containing 5000 users).
- Collaborate with Rael Cahn, Terry Sejnowski, Scott Makeig, Tzy-Ping Jung, Julie Onton, Stefan Debener, Robert Oostenveld, Andrew Sornborger, Simon Thorpe, Michele Fabre-Thorpe, Laurent Perrinet, Rufin VanRullen, Guillaume Rousselet, and Marc Mace.
Oct. 2004 Main lecturer for the first EEGLAB workshop on analysis of single-trial EEG data, La Jolla, CA. Teaching single-trial, independent component analysis and spectral analysis of EEG data for a total of 7 hours to a group of 30 participants from 11 countries (out of which 15 were professors or assisitant professors). fall 2004 Designed and taught the neuroscience course for the first year of the Master on consciousness studies of the renowned Birla Institute of technology and science, Pilani, India. Teaching neuroscience methodology, neural networks, binding problem, visual attention, neural correlates of consciousness, and neurofeedback (40 hours). See course slides. 1998-2000 Neuroscience tutorials for undergraduate students at Paul Sabatier University (Toulouse III, France). 75 hours. Topics involved neurons and synapses architecture and dynamics, auditory system, visual system anatomy and psychophysics, motor system, brain pharmacology.
1999-2000 Neuroscience lectures (undergraduate training for adults) at Paul Sabatier University (Toulouse III, France). 12 hours. Topics involved auditory system, visual system anatomy and psychophysics, motor system.
1999-2000 Statistics lectures/tutorials (half lecture, half tutorial) to undergraduate students. University of Mirail (Toulouse II, France). 40 hours.
1999 Tutorials for undergraduate students on experiment design at Paul Sabatier University (Toulouse III, France). 45 hours.
SkillsLanguages: Fluent in English and French. Working knowledge of Spanish and Persian.
Experiment: monkey psychophysics training (3 years), human EEG recording and experiment design (7 years).
Research Softwares: Expert knowledge of EEGLAB, Neuron, Statview, Neuroscan. Working knowledge of Besa 99, E-Prime, Genesis, Xpp.
Research software developedSpikeNET: neural network simulator package to build large networks of integrate and fire neurons (available at www.sccn.ucsd.edu/~arno/spikenet/).
EEGLAB: Matlab software for advanced EEG signal processing and single trial rejection (available at www.sccn.salk.edu/eeglab).
Link with industrySpikenet technology: Inventor (25%), shareholder of the company, and developer of the kernel for the original demo version of the software.
Lilly pharmaceutical: academic consulting (co-direction of bio-statistics student).
Personal InterestsSports: Swimming (6 years), TaeKwonDo (8 years), Roller Blades, Yoga.Hobbies: Guitar and drums, meditation.